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Importance: Single-nucleotide polymorphisms SNPs have demonstrated an association with breast cancer susceptibility, but there is limited evidence on how to incorporate them into current breast cancer risk prediction models. Objective: To determine whether a panel of 18 SNPs SNP18 may be used to predict breast cancer in combination with classic risk factors and mammographic density. De, Setting, and Participants: This cohort study enrolled a subcohort of women, aged 46 to 73 years, without a breast cancer diagnosis from the larger prospective cohort of the PROCAS study Predicting Risk of Cancer at Screening specifically to evaluate breast cancer risk-assessment methods.
The album is considered Sheeran's commercial breakthrough. He ly released five EPs independently. Jake Gosling and Sheeran produced the majority of the album, with additional production by American hip hop producer No I. Worldwide, the album has sold more than 4 million copies.
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